Can I mock object which is impossible to instantiate?

I am using some COM library in my C# which is bound to particular hardware and doesn't work without it. On development/testing computer I don't have that hardware. The method which is using library looks like this:

using HWSysManagerLib;
bool ProcessBias(HWSysManager systemManager, string hwPath)
{
    int handle = systemManager.OpenConfiguration(hwPath);
    ...
    // some magic goes here
    // return result
}

The question is, can I mock HWSysManager for test method and how? There are few methods only in HWSysManager and it wouldn't be problem to simulate their functionality for test. A tiny example would be great on how to mock it, if it's possible at all.