How to simulate a CRM plugin sandbox isolation mode in unit tests?

Context

I would like to write some unit tests against classes what will be utilized by CRM 2016 CodeActivity and Plugin classes. The final assembly will be registered in sandbox isolation mode.

I want to be sure if a test case is green when running unit tests, it will not be more restricted in sandbox isolation security restrictions when registered and run in CRM.

Question

Is there any way to simulate the sandbox isolation when running unit tests?